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How your baby's immune system develops

Key facts

  • Your baby's immune system is not fully developed when they are born, and will continue to develop as they grow.
  • During your third trimester of pregnancy, antibodies pass to your baby through your placenta, which help protect your baby for a short time after they are born.
  • When you are pregnant, vaccination against the flu and whooping cough is recommended — these help protect your baby after they are born.
  • Breastfeeding and vaccinating your baby can also help protect them from a serious illness.
  • On this page

    • What is the immune system?
    • How does a newborn baby's immune system form?
    • Do premature babies have the same immune system as full-term babies?
    • How can my baby’s immune system be made stronger?
    • Why is breastfeeding important for your baby’s immune system?
    • How does vaccination help build immunity?
    • Can diet and supplements help my baby’s immune system?
    • Are probiotics useful for immune health?
    • Resources and support

    What is the immune system?

    Your immune system is a network of cells and proteins that work together to protect your body and fight germs that cause infection.

    Germs such as bacteria and viruses are sometimes described as 'foreign'. Some germs can cause your baby to become sick.

    If bacteria or viruses get into your baby's body, their immune system acts quickly.

    White blood cells respond by recognising the germ as something foreign. They make special proteins called 'antibodies' that help fight the infection.

    Once these antibodies are made, the immune system 'remembers' the germ. This means the body can respond more quickly and effectively if the same germ returns. This memory is called 'immunity'.

    How does a newborn baby's immune system form?

    Your baby's immune system is not fully developed when they are born. As your baby grows, it gets stronger.

    During your third trimester of pregnancy, antibodies from your immune system are shared with your baby through the placenta. The type of antibodies that pass to your baby depends on your own immunity. In this way, your baby may be protected against the germs in your environment.

    Your antibodies help protect your baby when they are born. They stay in your baby's body for weeks or months after birth. Your antibodies can help your baby fight diseases before they get their first vaccines.

    Not all bacteria are harmful or cause disease. Some bacteria are helpful, including 'good bacteria' in your gut (digestive system) that help your immune system work well. They are passed on to your baby during a vaginal birth. This helps good bacteria establish in your baby's gut.

    After your baby is born, they can get more antibodies during breastfeeding, especially in colostrum (the first breast milk). Antibodies continue to be passed to your baby in breast milk.

    Do premature babies have the same immune system as full-term babies?

    Premature babies do not get as many antibodies through the placenta as full-term babies. Their immune systems are less strong.

    Premature babies are more likely to get sick from germs such as bacteria and viruses. Vaccinations for parents, family members and carers can help protect a premature baby from illness. Encourage family members and carers to talk to their doctor about booster vaccines.

    Premature babies should get their vaccines, following the same schedule as full-term babies.

    Visit the National Immunisation Program Schedule.

    How can my baby’s immune system be made stronger?

    The protection your baby gets at birth only lasts a short time. It will gradually go away after a few weeks or months.

    Just like adults, healthy babies make their own antibodies. Each time they are infected with a germ, their immune system starts to work. They make new antibodies that will protect them now and in the future.

    Immunity in a baby is not as strong as in adults — it takes time to fully develop. In the meantime, there are some important things you can do to protect your baby, like breastfeeding and getting vaccinated on time.

    FIND A HEALTH SERVICE — The Service Finder can help you find doctors, pharmacies, hospitals and other health services.

    Why is breastfeeding important for your baby’s immune system?

    Breast milk contains many good things to help build your baby's immune system. These include proteins, fats, and sugars. Breast milk also contains antibodies and probiotics.

    When you breastfeed, antibodies that your immune system makes to fight infection are passed to your baby in your breast milk. This is how your breast milk can protect your baby from infections they are exposed to.

    Breastfed babies have fewer infections. They also get over infections more quickly than formula-fed babies. While breastfeeding is good for your baby's developing immune system, it cannot fully protect them from all serious infections.

    Some people cannot breastfeed, or choose not to. Infant formula is another healthy option for babies.

    How does vaccination help build immunity?

    Vaccinating your baby is the safest and most effective way to protect them against many serious diseases.

    Vaccination causes an immune response in the same way that a virus or bacteria would, without your baby actually getting sick.

    The vaccine makes your baby 'immune'. If your baby is exposed to the germ in future, their immune system will remember it and an immune response will swing into action. It will fight off the disease and help prevent serious complications.

    Your baby's first vaccines are offered at birth, then at 6 weeks, 4 months and 6 months of age. Other vaccines and boosters are offered over the first few years of life.

    Learn more about vaccinations.

    Whooping cough vaccination during pregnancy

    You can have the whooping cough (pertussis) vaccine from 20 to 32 weeks of your pregnancy.

    This helps pass on immunity against whooping cough to your baby. This is how you can protect your baby from whooping cough even before they can have their first vaccines.

    Grandparents, family members and visitors who have not had a whooping cough vaccine in the past 10 years can get a booster vaccine against whooping cough. This can also help protect your baby.

    Influenza vaccination during pregnancy

    During pregnancy, you can also have the influenza ('flu') vaccine. The antibodies your body makes against the flu pass to your baby during pregnancy and in your breast milk. The flu vaccine is recommended and safe at all stages of pregnancy.

    RSV (respiratory syncytial virus) vaccination during pregnancy

    RSV vaccination is now recommended from 28 weeks of pregnancy (and up to 36 weeks). Some babies and young children may also be offered RSV antibody treatment, for example if:

    • you didn't have the RSV vaccine during pregnancy, or were vaccinated less than 2 weeks before giving birth
    • you did have the RSV vaccine during pregnancy, but your baby is at higher risk of getting very sick from RSV
    • your child is under 2 years old and has a medical condition that increases their risk of serious RSV illness

    Can diet and supplements help my baby’s immune system?

    In most cases, breast milk or formula provides all the vitamins and minerals your baby needs. Giving extra vitamins is not usually recommended for babies.

    Once your baby starts on solids, a range of fresh foods should be enough to keep their immune system healthy.

    This can include different types of pureed vegetables and fruits. Try to keep breastfeeding at the same time as starting solid food.

    Read more on introducing solid food.

    Are probiotics useful for immune health?

    Probiotics are live bacteria and yeasts. They are found in many foods and in some supplements. They can be purchased over-the-counter at a pharmacy, supermarket or health food store.

    Taking antibiotics kills some of the good bacteria in your gut. These bacteria are important for immunity. Some people think that probiotics can boost immunity after they have had antibiotics.

    Probiotics are safe to use in late pregnancy and after your baby is born. Research proving the benefits of probiotics for children is limited. Talk to your doctor before giving probiotics to your baby. Together you can decide if it is appropriate to give your baby probiotics.

    Resources and support

    • The Australian Breastfeeding Association has an information page about breastfeeding and immunity.
    • You can visit the Department of Health, Disability and Ageing for more information about childhood immunisation.
    • The Royal Children's Hospital Melbourne has a fact sheet about probiotics and babies.

    Languages other than English

    • The Sydney Children's Health Network fact sheet about common newborn concerns has been translated into many community languages.
    • Read more on childhood vaccinations in a range of languages at the NSW Multicultural Health Communication Service.

    Information for Aboriginal and/or Torres Strait Islander peoples

    • The Australian Breastfeeding Association has a collection of resources about breastfeeding for Aboriginal and/or Torres Strait Islander peoples.
    • Keeping Our Mob Healthy is a range of child health fact sheets developed specifically for Aboriginal children, young people and families.

    Speak to a maternal child health nurse

    Call Pregnancy, Birth and Baby to speak to a maternal child health nurse on 1800 882 436 or video call. Available 7am to midnight (AET), 7 days a week.

    • Jornal de pediatria — Immune system: development and acquisition of immunological competence
    • Cell — Stereotypic Immune System Development in Newborn Children
    • Frontiers in immunology — Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers
    • John Murtagh’s General Practice, 8th Edition — Chapter 6: Prevention in general practice
    • The Royal Australian and New Zealand College of Obstetricians and Gynaecologists — Pre-pregnancy and pregnancy-related vaccinations (C-Obs 44)
    • National Health and Medical Research Council — Infant Feeding Guidelines
    • Nutrients — Are Probiotics and Prebiotics Safe for Use during Pregnancy and Lactation? A Systematic Review and Meta-Analysis
    • The Journal of Microbiology and Biotechnology (JMB) — Role of Probiotics in Human Gut Microbiome-Associated Diseases
    • Jornal de pediatria — An update on vaccination in preterm infants
    • Best practice & research. Clinical obstetrics & gynaecology — Vaccines – safety in pregnancy
    • The Royal Children's Hospital Melbourne — Clinical practice guidelines: Whooping cough (pertussis)
    • The Royal Australian College of General Practitioners — Probiotics for the prevention of antibiotic-associated diarrhoea in adults and children
    • Australian Immunisation Handbook — Vaccination for preterm infants
    • Australian Immunisation Handbook — Respiratory syncytial virus (RSV)

    Find out how we develop and review our content.


    Last reviewed: October 2025


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